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- Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent.
The process of gene silencing is important for the differentiation of many different types of cells. MedicineNet, Inc.
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- Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. - biotech-info.net
by - The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? - The Thomson Corporation
by - In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. - ScienceDaily LLC
by Compare [close] - Romanian
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- ...cand metilarea are loc in ansamblu de baze citozina - guanina aflate in regiunea promoter a unei gene, se produce fenomenul de silentiere, cu stoparea biosintezei ARNm si proteinei corespunzatoare codate de gena respectiva. Sub influenta factorilor alimentari epigenetici pot avea loc metilari anormale, care sunt implicate in fenomenele de imbatranire si aparitia a numeroase maladii incluzand: cancerele, boli cardiovasculare, metabolice, degenerative (Alzheimer, Parkinson) s.a.. journal - by Mihaela Petrican
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- Fenomenele de silenţiere a genelor au furnizat ştiinţei plantelor noi instrumente pentru descoperirea mecanismelor epigenetice care reglează expresia genelor. Un aspect remarcabil al silenţierii genelor este diversitatea mecanismelor care apar, ca fiind rezultatul a numeroase interacţii între acizii nucleici care se află în nucleu dar şi în citoplasmă. (Kooter J.M., Matzke M.A., Mayer P, 2001). Genomul plantelor se caracterizează prin prezenţa a numeroase elemente transpozabile, iar multe dintre aceste elemente sunt inactivate sau „silenţiate”. Studii recente au pus în evidenţă noi direcţii cu privire la reglarea elementelor transpozabile. De exemplu, la Caenorhabditis elegans, elementele transpozabile sunt silenţiate post-transcripţional în timp ce elementele transpozabile de la Arabidopsis sunt „silenţiate” prin factori de remodelare ai cromatinei. Aceste observaţii au pus în evidenţă corelarea funcţională între silenţierea genelor şi supresia elementelor transpozabile şi au avut implicaţii majore pentru înţelegerea menţinerii integrităţii genomului. - ebooks.unibuc.ro/biologie/ProgreseVolumu
by Mihaela Petrican - În 1990 (R. Jorgensen) a pus în evidenta ARN-interferent, un fel de rascruce de cai metabolice, având o structura asemanatoare ARN-mesager, dar forma dublu catenara ca a moleculei de ADN. ARN-interferent este un puternic factor de silentiere a exprimarii genice. - journal
by Mihaela Petrican - Related KudoZ question
Compare [close] - Swedish
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- När en gen tystas ned, genom t.ex. RNA-interferens, talar man på svenska om genavstängning (gene silencing). Hos växter som används som livsmedel kan man blockera eller reducera bildningen av oönskade ämnen, till exempel sådana som kan framkalla allergi. Djurmodeller av vissa sjukdomar, till exempel högt blodkolesterolvärde, kan påverkas gynnsamt genom genavstängning. I en klinisk prövning använder man RNA-interferens för att blockera en gen som är verksam vid en näthinnesjukdom. Nationalencyklopedin: Nobelpriset 2006 - by egj_translation
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Compare [close] - Albanian
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- Heshtja e gjeneve është procesi i ndërprerjes ose i ndrydhjes së shprehjes së një gjeni, në nivelin e transkriptimit ose të përkthimit.
NCBI - by Juliana Cullafiq
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- Po behen tentativa per kurimin e semundjeve si te Parkinson-it dhe te Hantington-it duke perdorur terapine gjenike me heshtje te gjeneve me ane te copezave te shkurtera te ARN qe jane quantur siARN (ARN nderhyresa) qe kane aftesi te futen ne mes te enzimave ose faktoreve te ndryshem dhe te bllokojne shfaqjen e tyre.
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by Juliana Cullafiq - Related KudoZ question
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