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- Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent.
The process of gene silencing is important for the differentiation of many different types of cells. MedicineNet, Inc.
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- Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. - biotech-info.net by
- The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? - The Thomson Corporation by
- In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. - ScienceDaily LLC by
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- Silenciamiento génico o genético
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- Silenciamiento génico es el mecanismo que regula la expresión genética, mediante el cual el ARN regula la expresión de ciertas regiones del ADN y define qué proteínas están presentes en la cédula. Own research - by Conchita Monedero
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- El silenciamiento genético es un proceso sumamente importante en la mayoría de los organismos. Si una célula expresara todos y cada uno de sus genes sin una cierta regulación, el desorden generado en el interior de la misma podría conducir a una muerte celular inevitable. - ARN de interferencia y su importancia en by Conchita Monedero
- Análisis del silenciamiento génico en infecciones virales en plantas: proteínas virales supresoras en un sistema silenciado. En los últimos años se ha descrito un fenómeno de regulación de la expresión génica en eucariotas genéricamente conocido como silenciamiento por RNA o ribosilenciamiento. - Archivo Digital UPM by Conchita Monedero
- El mecanismo de silenciamiento génico transcripcional y postranscripcional está presente en la mayoría de los organismos eucariotas y fue descubierto a finales de la década de los 1980s. - Portales médicos.com by Conchita Monedero
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Compare [close] - German
- Biology (-tech,-chem,micro-)
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- Gen-Silencing (Gen-Stilllegung)
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- Als Gen-Silencing (Gen-Stilllegung) wird ein Vorgang aus der Genetik bezeichnet, bei dem Gene aktiv abgeschaltet werden. Es handelt sich um einen (epigenetischen) Prozess der Genregulation. Wikipedia - by Harald Moelzer (medical-translator)
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- Gene Silencing
Inaktivierung von Genen
Wenn Gene inaktiv werden, ohne dass sich der entsprechende DNA-Abschnitt verändert hat, spricht man von gene silencing. Dabei handelt es sich nicht um ein spezielles Phänomen in transgenen Pflanzen, sondern um natürliche Mechanismen, mit deren Hilfe Pilze, Tiere und Pflanzen ihre eigenen Gene regulieren. Sie können sich damit aber auch gegen fremdes Erbmaterial zur Wehr setzen. Das gene silencing basiert auf epigenetischen ("über" der DNA-Information gelegenen) Regulationsmechanismen und ist verwandt mit der RNA-Interferenz. - Biosicherheit.de by Harald Moelzer (medical-translator)
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Compare [close] - Chinese
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- "基因沉默" 英文对照
gene - silencing; gene silence;
"基因沉默" 在学术文献中的解释
1、基因沉默是指生物体中特定基因由于种种原因不表达.它发生在两种水平上,一种是转录水平上的基因沉默,另一种是转录后基因沉默
文献来源
2、在转基因植物中外源基因不能正常表达,呈失活状态的现象称为基因沉默.造成基因沉默的因素主要有插入位置、重复序列和甲基化.基因沉默一般可以归为转录水平和转录后水平上
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3、这种基因失活的现象称为基因沉默.其沉默机制可分为以下3种:位置效应、转录水平的基因沉默、转录后水平的基因沉默.建议国家“863”项目投入更多的经费用于基因沉默机制、防止基因沉默发生的研究
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http://define.cnki.net - by Adsion Liu
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