English to Russian Medical Medical: Pharmaceuticals pharmacology

The lack of activity of ibuprofen in the hotplate test shows that its analgesic activity is predominantly peripheral rather than central.
In addition to anti-inflammatory action based on COX inhibition at the inflamed site, ibuprofen is likely to have further effects on the inflammatory process, such as inhibition of migration of leukocytes into inflamed sites.
These further actions may also be mediated by modulation of arachidonate-derived mediators in specific cell types

Не совсем ясен смысл фразы «mediated by modulation»…
…дополнительные воздействия могут также быть опосредованы модуляцией провоспалительных медиаторов арахидоновой кислоты…?