Jul 7, 2007 15:31
16 yrs ago
3 viewers *
Spanish term
United Kingdom
making sense of it
Spanish to English
Medical
Medical: Pharmaceuticals
I have read this through numerous times now and it is just not clear to me. I have included a draft and hope that someone can help me make sense of it.
En un segundo estudio de 14 días, con determinación de dosis orales en ratas macho con PLA 695 en el vehículo Capryol/Solutol/Cremophor, PLA 695 se administró en dosis de 300, 600 ó 1000 mg/kg/día en formulación de vehículo no diluido en volúmenes de dosis de 1,5, 3, 5 mL/kg vehículo no diluido de 300, 600 y 1000 mg/kg/día respectivamente, y dosis de 300 ó 600 mg/kg/día en formulación de vehículo diluido en agua (7,5% a 9,375% de Capryol 90, 11,2% a 14,06% de Cremophor EL, 11,25% a 14,06% de Solutol HS 15 y agua purificada Tipo I) en volúmenes de dosis de 4 y 8 mL/kg de vehículo diluido en agua a 300 y 600 mg/kg/día, respectivamente.
In a second 14-day oral dose-determination study in male rats with PLA-695 in the Capryol/Solutol/Cremophor vehicle, PLA-695 was administered at doses of 300, 600 or 1000 mg/kg/day in an undiluted vehicle formulation at 1, 5, 3, 5 mL/kg dose volumes of the undiluted vehicle at 300, 600 and 1000 mg/kg/day respectively, and doses of 300 or 600 mg/kg/day in a formulation of the vehicle diluted in water (7.5% to 9.375% of Capryol 90, 11.2% to 14.06% of Cremophor EL, 11.25% to 14.06% of Solutol HS 15 and Type 1 purified water) at 4 and 8 mL/kg dose volumes of the vehicle diluted in water at 300 and 600 mg/kg/day, respectively.
Many thanks
En un segundo estudio de 14 días, con determinación de dosis orales en ratas macho con PLA 695 en el vehículo Capryol/Solutol/Cremophor, PLA 695 se administró en dosis de 300, 600 ó 1000 mg/kg/día en formulación de vehículo no diluido en volúmenes de dosis de 1,5, 3, 5 mL/kg vehículo no diluido de 300, 600 y 1000 mg/kg/día respectivamente, y dosis de 300 ó 600 mg/kg/día en formulación de vehículo diluido en agua (7,5% a 9,375% de Capryol 90, 11,2% a 14,06% de Cremophor EL, 11,25% a 14,06% de Solutol HS 15 y agua purificada Tipo I) en volúmenes de dosis de 4 y 8 mL/kg de vehículo diluido en agua a 300 y 600 mg/kg/día, respectivamente.
In a second 14-day oral dose-determination study in male rats with PLA-695 in the Capryol/Solutol/Cremophor vehicle, PLA-695 was administered at doses of 300, 600 or 1000 mg/kg/day in an undiluted vehicle formulation at 1, 5, 3, 5 mL/kg dose volumes of the undiluted vehicle at 300, 600 and 1000 mg/kg/day respectively, and doses of 300 or 600 mg/kg/day in a formulation of the vehicle diluted in water (7.5% to 9.375% of Capryol 90, 11.2% to 14.06% of Cremophor EL, 11.25% to 14.06% of Solutol HS 15 and Type 1 purified water) at 4 and 8 mL/kg dose volumes of the vehicle diluted in water at 300 and 600 mg/kg/day, respectively.
Many thanks
Proposed translations
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Proposed translations
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It is not very good english but the reason is the original. See if now it makes sense for you:
"In a second study of 14-day in male- rats with determination of oral doses using PLA-695 in Capryol/Solutol/Cremophor vehicle, the PLA-695 being administered at doses of 300, 600 or 1000 mg/kg/day in an undiluted vehicle formulation with dose volumes of 1.5, 3,.5 mL/kg of the undiluted vehicle for 300, 600 and 1000 mg/kg/day respectively, and at doses of 300 or 600 mg/kg/day in a formulation with the vehicle diluted in water (7.5% to 9.375% of Capryol 90, 11.2% to 14.06% of Cremophor EL, 11.25% to 14.06% of Solutol HS 15 and Type 1 purified water) at 4 and 8 mL/kg dose volumes of the vehicle diluted in water for 300 and 600 mg/kg/day, respectively."
"In a second study of 14-day in male- rats with determination of oral doses using PLA-695 in Capryol/Solutol/Cremophor vehicle, the PLA-695 being administered at doses of 300, 600 or 1000 mg/kg/day in an undiluted vehicle formulation with dose volumes of 1.5, 3,.5 mL/kg of the undiluted vehicle for 300, 600 and 1000 mg/kg/day respectively, and at doses of 300 or 600 mg/kg/day in a formulation with the vehicle diluted in water (7.5% to 9.375% of Capryol 90, 11.2% to 14.06% of Cremophor EL, 11.25% to 14.06% of Solutol HS 15 and Type 1 purified water) at 4 and 8 mL/kg dose volumes of the vehicle diluted in water for 300 and 600 mg/kg/day, respectively."
Note from asker:
| Thank you very much for having a go at this one Vepalm - also, you are completely right about the decimal point (should have spotted that really). Thanks again!! |
Peer comment(s):
| neutral |
Lia Fail (X)
: I'm afraid I prefer Adam's English
26 mins
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Ths in any form
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| neutral |
Roberto Rey
: Yes I'm also afraid that Adam's English is a lot better..
59 mins
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Ths in any form
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| agree |
Leda Roche
1 hr
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ths
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4 KudoZ points awarded for this answer.
Comment: "Thanks for your help Vepalm!"
Discussion
as a dose of 300, 600 or 1000 mg/kg/day in an undiluted vehicle formulation at 1.5, 3 and 5 mL/kg dose volumes of the undiluted vehicle at 300, 600 and 1000 mg/kg/day respectively,
and
as a dose of 300 or 600 mg/kg/day in a water-diluted vehicle formulation (7.5% to 9.375% of Capryol 90, 11.2% to 14.06% of Cremophor EL, 11.25% to 14.06% of Solutol HS 15, and Type 1 purified water) at 4 and 8 mL/kg dose volumes of the water-diluted vehicle at 300 and 600 mg/kg/day, respectively.
You have cleared up one issue with the decimal point - many thanks.