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Specialized in Medical and Health Sciences translations.
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English to Portuguese: Role of paraventricular nucleus in exercise training-induced autonomic modulation in conscious rats General field: Medical Detailed field: Medical (general)
Source text - English The paraventricular nucleus (PVN) of the hypothalamus is an important site for autonomic regulation, where gamma-aminobutyric acid (GABA) system plays an important role. The central mechanisms underlying modulatory effects of exercise training have yet to be characterized. Our objective was to analyze the effects on the autonomic modulation and hemodynamic parameters after bicuculline or muscimol injections into the PVN of sedentary (control, C) and previously submitted to swimming training (ST) rats. After ST protocol, adult male Wistar rats, instrumented with guide cannulas to PVN and femoral artery and vein catheters were submitted to mean arterial pressure (MAP) recording. The exercise training reduced the LF oscillations in normalized units and increased the HF oscillations in absolute and normalized units. Compared with the C group, muscimol microinjections in the ST group promoted a higher decrease in MAP (C=−14±1 vs. ST=−28±4 mm Hg). Spectral analysis of HR (pulse interval) showed that the muscimol microinjections also reduced LF and HF oscillations in absolute units in both groups. Bicuculline microinjections increased the systolic arterial pressure (C=155±5, ST=164±5mmHg) in ST compared with the C group. Bicuculline injections also increased the LF oscillations of HR in absolute units in C and ST groups. Meanwhile, in normalized units only the ST group showed an increase in the LF oscillations. Our data showed that PVN has an important role in autonomic modulation after exercise training.
Keywords: Bicuculline, Arterial pressure, Muscimol, Sympathetic nervous system, Heart rate variability
Translation - Portuguese O núcleo paraventricular do hipotálamo (PVN) é um local importante para a regulação autônoma, onde o ácido gama - aminobutírico desempenha um papel importante. Os mecanismos centrais subjacentes aos efeitos modulatórios do treinamento físico ainda precisam ser caracterizados. Nosso objetivo foi analisar os efeitos da modulação autônoma e os parâmetros hemodinâmicos após injeções de bicuculina ou muscimol no PVN de ratos sedentários (controle, C) e previamente submetidos ao treinamento físico por natação (T). Após o protocolo de treinamento, ratos Wistar, adultos, machos, com cânulas-guia implantadas ao PVN e com cateteres nas veia e artéria femoral foram submetidos ao registro de pressão arterial média (PAM). O exercício físico diminuiu as oscilações de LF em unidades normalizadas e aumentou as oscilações em HF em unidades absolutas e normalizadas. Comparado com o grupo C, as injeções de Muscimol no grupo treinado (T) promoveram uma maior diminuição na PAM ( c= 14±1 vs. T= 28±4 mmHg). A análise espectral de HR (intervalo de pulso) mostrou que as microinjeções de Muscimol também reduziram as oscilações de LF e HF em unidades absolutas em ambos os grupos. As microinjeções de Bicuculina aumentaram a pressão arterial sistólica ( C= 155±5, T= 164±5 mmHg) no grupo T comparado com o grupo C. As injeções de Bicuculina também aumentaram as oscilações de LF do HR em unidades absolutas nos grupos C e T. Entretanto, em unidades normalizadas apenas o grupo T mostrou um aumento nas oscilações de LF. Nossos dados demonstraram que o PVN tem um papel importante na modulação autônoma após o treinamento físico.
Palavras-chave: Bicuculina, Pressão Arterial, Muscimol, Sistema Nervoso Simpático, variabilidade da Frequência Cardíaca.
English to Portuguese: Musical Wicked Review General field: Art/Literary
Source text - English Let’s go back in time a bit to analyze one of the most successful musicals in history, comparable to a modern Phantom of the Opera or Les Miserables: this week’s musical is the 2003 phenomenon Wicked. Some people make recognize Wicked as having a somewhat familiar story; that’s because it is the story of the lives of the Wicked Witch of the West and the Good Witch of the North from the classic 1939 film “The Wizard of Oz”. However, the complicated story takes place before the story of Dorothy occurred. It begins with the repulsive birth of Elphaba, the future Wicked Witch, who is born with green skin. Elphaba grows up with her younger sister, Nessarose, who is paralyzed from the waist down and conformed to a wheelchair, and soon both of them are enrolled at Shiv University. Once there, Elphaba’s classmates immediately reject her for her appearance, including the school’s most popular and selfish girl Galinda, the future Good Witch of the North. Elphaba and Galinda are regrettably assigned as roommates, despite their hatred of one another, however they eventually grow to respect each other. One day, a furious Elphaba discovers that she has magical powers, and the school’s headmistress, Madame Morrible, assures here that with her power she will be able to work for the magical Wizard of Oz.
Translation - Portuguese Vamos voltar um pouco no tempo para analisar um dos musicais de mais sucesso na história, comparável ao moderno Fantasma da Ópera ou Os Miseráveis: o musical dessa semana é o fenômeno de 2003, Wicked. Algumas pessoas podem reconhecer em Wicked uma história um tanto familiar; isso porque é a história das vidas da Bruxa Má do Oeste e a Bruxa Boa do Norte do filme clássico de 1939 “O mágico de Oz”. Porém, a complicada história acontece antes da história de Dorothy.
Começa com o nascimento repulsivo de Elphaba, a futura Bruxa Má, que nasce com a pele verde. Elphaba cresce com sua irmã mais nova, Nessarose, que tem paralisia da cintura para baixo e está sujeita a uma cadeira de rodas, e logo ambas estão inscritas na Universidade Shiv. Uma vez lá, os colegas de classe de Elphaba imediatamente a rejeitam por causa de sua aparência, incluindo a garota mais popular e egoísta da escola Galinda, a futura Bruxa Boa do Norte. Elphaba e Galinda infelizmente se tornam colegas de quarto, apesar do ódio que sentem uma pela outra, porém no final elas acabam se respeitando. Um dia, uma Elphaba furiosa descobre que tem poderes mágicos, e a diretora da escola Madame Morrible lhe garante que com seus poderes ela poderá trabalhar para o talentoso Mágico de Oz.
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Years of experience: 14. Registered at ProZ.com: Dec 2012.
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Technical translator with academic and professional formation in Health and Life Sciences. Experienced in translation and proofreading of documents related to Health, Medicine and areas alike. Understand several translation tools, including on-line tools preferred by specific clients. Extremely attentive to details, is a capable proofreader. Translate from 2,500 to 3,000 words a day. Competent to follow style guides, glossaries, detailed instructions and specific translation memories. Organizer of the first and only meeting about Medical Translations in Brazil and manager at a Facebook page about medical translation.
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