Glossary entry (derived from question below)
English term or phrase:
Fab arm exchange
Russian translation:
обмен антиген-связывающими фрагментами/Fab-фрагментами
Added to glossary by
flowerlsv
Oct 3, 2014 16:29
9 yrs ago
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English term
Fab arm exchange
English to Russian
Science
Genetics
антитела
Humanized antibody or a functional fragment thereof comprises a heavy chain constant region with a mutation in the hinge region, particularly a mutation in the hinge region which prevents Fab arm exchange and thus generation of bi-specific antibodies.
Proposed translations
(Russian)
| 4 | обмен антиген-связывающими фрагментами/Fab-фрагментами |
Andrey Svitanko
|
Proposed translations
33 mins
Andrey Svitanko
Poland
Poland
Native in Russian
Works in field
Poland
RU EN UKR
Native in: Russian 
Works in: English to Russian, Russian to English, Ukrainian to English, and 8 more.
Related KudoZ points
:
93
Selected
обмен антиген-связывающими фрагментами/Fab-фрагментами
Fab-arm exchange
A physiological process that results in the reassortment of human IgG4 half-molecules. This process occurs naturally in vivo and can be mimicked in vitro. As a functional consequence of this process, Fab arms containing antigen-binding sites are exchanged between antibody molecules leading to novel binding combinations in the newly formed, bispecific antibody. The DuoBody® technology is based on this naturally occurring process for generating bispecificity.
http://www.genmab.com/duobody/glossary
http://www.genmab.com/duobody/biology
https://ru.wikipedia.org/wiki/Антитела
При помощи протеазы папаина антитела можно расщепить на два Fab (англ. fragment antigen binding — антиген-связывающий фрагмент) и один Fc (англ. fragment crystallizable — фрагмент, способный к кристаллизации).
A physiological process that results in the reassortment of human IgG4 half-molecules. This process occurs naturally in vivo and can be mimicked in vitro. As a functional consequence of this process, Fab arms containing antigen-binding sites are exchanged between antibody molecules leading to novel binding combinations in the newly formed, bispecific antibody. The DuoBody® technology is based on this naturally occurring process for generating bispecificity.
http://www.genmab.com/duobody/glossary
http://www.genmab.com/duobody/biology
https://ru.wikipedia.org/wiki/Антитела
При помощи протеазы папаина антитела можно расщепить на два Fab (англ. fragment antigen binding — антиген-связывающий фрагмент) и один Fc (англ. fragment crystallizable — фрагмент, способный к кристаллизации).
Note from asker:
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4 KudoZ points awarded for this answer.
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