Apr 8, 2009 11:45
15 yrs ago
French term
mpt_21 (X)
DIMINUT. ACT. CELL. GO.
French to English
Medical
Medical (general)
Pathology Report Data
This abbreviated term is under the heading 'PITUITARY' in the data listing.
Proposed translations
(English)
| 2 +3 | reduction in the level of cellular activity |
NKW (X)
|
Proposed translations
+3
35 mins
Selected
reduction in the level of cellular activity
It looks as if the writer is reporting a drop in cellular activity, but I have no idea what is meant by 'GO' unless it refers to 'gonadique' ('gonadal'). Given the complex relationships between hormone-secreting cells in different parts of the body, this is a possibility.
Peer comment(s):
| agree |
SJLD
: maybe G0 (zero) phase q.v.
1 hr
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Thank you, particularly for the suggestion re the possibility of 'G0' rather than 'GO'
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| agree |
:::::::::: (X)
1 hr
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Many thanks, Dr. Jones
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| agree |
Lionel_M (X)
: I agree with Nick and would translate GO as gonadic (we are in pituitary and there no way to check for G zero phase)
2 hrs
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Thank you.
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3 KudoZ points awarded for this answer.
Comment: "Thank you for your help."
Reference comments
20 hrs
Reference:
G0 phase and cell proliferation in pituitary tumours
http://www.eje-online.org/cgi/content/full/156/2/143
Markers of proliferation Nuclear proteins, such as Ki-67 and proliferating cell nuclear antigen (PCNA) are often used to assess proliferative activity of tumour cells (16). Ki-67 is recognised by the MIB-1 monoclonal antibody and it is expressed throughout the cell cycle in G1, S, G2 and M phases, but not the quiescent G0 phase (28, 35). The percentage of cells immunostained for this protein (Ki-67/MIB-1 labelling index) represents a reliable marker of proliferative activity (36).
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Note added at 22 hrs (2009-04-09 10:39:55 GMT)
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See Ki-67
http://www.millipore.com/catalogue/item/ab9260
Markers of proliferation Nuclear proteins, such as Ki-67 and proliferating cell nuclear antigen (PCNA) are often used to assess proliferative activity of tumour cells (16). Ki-67 is recognised by the MIB-1 monoclonal antibody and it is expressed throughout the cell cycle in G1, S, G2 and M phases, but not the quiescent G0 phase (28, 35). The percentage of cells immunostained for this protein (Ki-67/MIB-1 labelling index) represents a reliable marker of proliferative activity (36).
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Note added at 22 hrs (2009-04-09 10:39:55 GMT)
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See Ki-67
http://www.millipore.com/catalogue/item/ab9260
Discussion