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English to Portuguese: English to Portuguese: Vasopressin and oxytocin secretion after osmotic and hypovolemic stimuli in sepsis surviving animals General field: Science Detailed field: Science (general)
Source text - English Many clinical and experimental studies reported the increase of plasma vasopressin (AVP) concentration in the early phase of sepsis, as an attempt to restore blood pressure that begins to decrease at this stage. However, in a later stage of the disease, the hormone concentrations are reduced even under a state of progressive hypotension, one of the major stimulus for the increase of secretion of this hormone. This pattern of impaired hormonal secretion during sepsis also seems to happen to the other pituitary hormone, Oxytocin (OT). The aim of this study was to evaluate the secretion of the hormones AVP and OT after osmotic and hipovolemic stimuli in sepsis surviving animals. Sepsis was induced by cecal ligation and perforation (CLP) (1 perforation with 14G needle) and the animals observed for 10 days. The survivors were submited to osmotic stimulus by dehydration (privation of drinking water from the Cage) for two days, or hipovolemic by intraperitoneal (i.p) injection of polyethylene glycol (PEG) (PEG-4000, 200mg/ml of PBS) for 90 minutes. The control animals were hydrated or that received intraperitoneal injection of PBS 0,01M. After the stimuli, the animals were decapitated for the collection of blood and neurohypophysis, for the analysis of hematocrit, serum sodium, plasma osmolality and hormonal analysis of AVP and OT in the plasma and neurohypophysis. Results: Sepsis surviving animals maintained the capacity of answering the stimulus with AVP secretion. But these animals presented a lowered secretion of OT after dehydration, while they presented no alterations in secretion after volemic stimulus. Conclusion: Sepsis surviving animals presented alterations in the pattern of hormonal answer for the osmotic stimulus, with lowered secretion of OT. apparently there are no alterations in the pattern of a hormonal secretion after hypovolemia.
Translation - Portuguese Vários estudos clínicos e experimentais relatam o aumento das concentrações plasmáticas de vasopressina (AVP) na fase inicial da sepse como tentativa de restabelecer a pressão sanguínea que nesta fase começa a diminuir. Porém, em uma fase mais tardia da doença, as concentrações do hormônio estão reduzidas, mesmo sob um quadro de hipotensão progressiva, um dos principais estímulos para aumento da secreção deste hormônio. Este padrão de secreção hormonal alterada também parece ocorrer com o outro hormônio neurohipofisário, a Ocitocina (OT). O objetivo deste trabalho foi analisar a secreção dos hormônios AVP e OT após estímulos osmótico e hipovolêmico em animais sobreviventes à sepse. A sepse foi induzida pelo método de ligadura e perfuração cecal (CLP) (1 perfuração com agulha 14G) e os animais observados por 10 dias. Os sobreviventes foram submetidos à estímulo osmótico por desidratação (retirada de água para beber da gaiola) por dois dias, ou hipovolêmico por injeção intraperitoneal (i.p) de Polietileno glicol (PEG) (PEG-4000, 200mg/ml de PBS) por 90 minutos. Os animais controle foram hidratados ou receberam injeção intraperitoneal de PBS 0,01M. Após os estímulos, os animais foram decapitados para coleta de sangue e neurohipófise, para as análises de hematócrito, sódio sérico, osmolalidade plasmática e dosagem hormonal de Vasopressina e Ocitocina plasmática e neurohipofisária. Resultados: os animais sobreviventes à sepse mantiveram a capacidade de responder aos estímulos com relação à secreção de AVP. Porém, estes animais apresentaram uma secreção diminuída de OT após desidratação, embora nenhuma alteração de secreção aparente ao estímulo volêmico. Conclusão: Animais sobreviventes à sepse apresentam alterações no padrão de resposta hormonal do eixo Hipotálamo-Neurohipofisário ao estímulo osmótico, sem aparente alteração quando o estímulo é volêmico, sugerindo que seus osmorreceptores encontram-se alterados.
My name is Lucas Favaretto Tazinafo. I have a PhD in Immunology and Pathophysiology from the University of São Paulo, Brazil. I have ten years of experience as a research scientist (medical area) and four as a full-time freelance translator from English to my native language, Brazilian Portuguese.
The translator career came naturally to me as a combination of my studying in English since childhood and my academic background, which led me to specialize in Health, Science and Medical Devices. Nowadays, I am a fully recommended translator on SmartCat and I have a Plus Membership on Proz.
My commitment is to deliver cost effective and high quality jobs.
I am a motivated worker, a multidisciplinary person, one that always searches for new qualifications.
Highlights:
Quality-oriented
Responsible
Attentive to details
Quick to learn new tools
Familiar with SmartCat, Oneforma and Trados
Some of the projects I have worked on include:
User’s Manual for Medical devices
Short vídeos subtitles
Clinical trials
Interview transcription
MTPE for AI training
Instructions for a healthier work environment
Pharmaceutical product’s flyers and brochures
Employee training material
Keywords: Portuguese, Brazil, medical, science, physiology, endocrinology, health, pathophysiology, parasitology, biomedicine. See more.Portuguese, Brazil, medical, science, physiology, endocrinology, health, pathophysiology, parasitology, biomedicine, pharmaceutical, biology, video games, public health, safety, localization, user's manual.. See less.
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