This site uses cookies.
Some of these cookies are essential to the operation of the site,
while others help to improve your experience by providing insights into how the site is being used.
For more information, please see the ProZ.com privacy policy.
VIA AILooking for an interpreter?
Remoto by ProZ.com connects you with an identity-verified interpreter by video or phone in about 60 seconds — 300+ languages, on demand or booked ahead.
Try Remoto »
Member since Sep '25
Working languages:
German to English
Client-vendor relationship recorded successfully!
Grahame Larkin MD has been added to your list of hired vendors.
German to English: Imaging of Bones and Joints, Thieme International General field: Medical
Source text - German Metabolische, hormonelle und toxisch bedingte Osteopathien
Metabolische, hormonelle und toxisch bedingte Osteopathien
801 Osteoporose
Die Osteoporose ist eine systemische Skeletterkrankung, die durch eine niedrige Knochenmasse und eine Verschlechterung der Mikroarchitektur des Knochens charakterisiert ist; das hat eine erhöhte Knochenbrüchigkeit zur Folge (WHO-Definition von 1994; s. Literatur im Internet).
> PATHO. Die Osteoporose stellt eine multifaktorielle Erkrankung dar, die jedoch der gewissenhaften differenzialdiagnostischen Abklärung bedarf. Grundsätzlich liegt der Osteoporose ein Missverhältnis zwischen Knochenaufbau und -abbau (sog. Remodeling) zugrunde. Dabei kann zwischen Osteoporoseformen mit einem erhöhten Knochenumsatz (High Turnover) und solchen mit vermindertem 1Abb. 8.1 und Abb. 8.2). Die Folgen sind der Verlust der biomechani schen Kompetenz und eine erhöhte Fragilität; das bedingt eine pathologisch gesteigerte Knochenbrüchigkeit. Spongiöse Mikrofrakturen sind Ausdruck der knöchernen Belastungsinsuffizienz. Der Heilungsversuch besteht in Mikrokallusformationen Abb. 8.3); dies kann jedoch die zerstörte Mikroarchitektur nicht wieder restaurieren.
8,101 Einteilung und Klinik der Osteoporose
Es gibt mehrere Einteilungs- und Graduierungssysteme der Osteoporose, die sich zum Teil überlappen. Die Osteoporose kann nach folgenden Kriterien eingeteilt werden:
• Regionalität und Ausdehnung (z. B. Inaktivitätsosteoporose, transitorische Osteoporose, CRPS)
• Alter des Auftretens (z. B. idiopathische juvenile Osteoporose, postmenopausale Osteoporose, senile Osteoporose)
• Knochenumbaugeschwindigkeit (High und Very high Turnover, Low Turnover)
392
www.thieme.de/bohndorf-radiologische-diagnostik
• Schweregrad der Osteoporose (normal, Osteopenie, präklinische Osteoporose und klinisch-manifeste Osteoporose; Schweregrade 0-3 nach Minne)
• Knochenhistologie
• Ätiologie
Dabei hat sich unter praktikablen Gesichtspunkten die ätiologische Einteilung durchgesetzt:
• Primäre Osteoporose: Hierunter fallen die postmenopausale und die senile Osteoporose sowie die primäre Osteoporose des Mannes. Sie ist die häufigste Form und hat multifaktorielle Ursachen und Risikofaktoren, obgleich zum Teil pathogenetische Einzelfaktoren bereits bekannt sind. Sie betrifft das gesamte Skelett, besonders jedoch die Wirbelsäule und die stammnahen Extremitäten.
• Sekundäre Osteoporose: Sie ist wesentlich seltener (etwa 5% der Fälle), führt aber häufiger zu osteoporotischen Frakturen. Ihr liegt entweder eine Grunderkrankung zugrunde oder sie ist alimentär, nutritiv-toxisch, medikamentös (z.B. Glukokortikoide) oder genetisch bedingt (z.B. Turner-Syndrom, Osteogenesis imperfecta). Typische Erkrankungen mit einem erhöhten Osteoporoserisiko sind Hypogonadismus, Hyperparathyreoidismus, Morbus Cushing, Hyperthyreose, chronische Malabsorptionssyndrome, chronisch-entzündliche Erkrankungen, Malignome (vor allem das multiple Myelom) und Speicherkrankheiten.
KLINIK. Bis auf wenige Ausnahmen verläuft der Knochenmassenschwund klinisch asymptomatisch. Erst mit
Translation - English
Metabolic, Hormonal, and Toxic Bone Disorders
801 Osteoporosis
Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility (WHO definition from 1994; see References for Chapter 8.1).
Pathology. Osteoporosis is a multifactorial disease requiring a careful diagnostic work-up. Basically, osteoporosis is due to an imbalance between bone resorption and bone formation (remodeling). A distinction is made between types ofosteoporosis with increased bone turnover (high turnover) and those with reduced bone turnover (low turnover).
Whereas the bone mass of an adult consists of about 80% compact/cortical bone and only 20% cancellous (trabecular) bone, the latter is considerably more active with regard to bone metabolism. Trabecular bone is particularly susceptible to processes involving bone resorption because of its 10-fold greater surface area compared with cortical bone.
Osteoporosis involves not only a loss of bone mass but also thinning and a conversion of the originally plate-shaped trabeculae into rod-shaped trabeculae and the appearance of perforating resorptive lacunae, resulting in a loss of 3D networking Figs. 8.1 and > 8.2). The result is loss of biomechanical competence and increased fragility; this is the reason for pathologically increased bone fragility. Trabecular microfractures indicate a failure of the bone when subjected to load-bearing. The formation of microcallus is an attempt to produce healing Fig. 8.3), although this process is not capable of restoring the destroyed microarchitecture.
8.101 Classification and Clinical
Presentation of Osteoporosis
There are several classification and grading systems for osteoporosis, some of which overlap. Osteoporosis may be classified using the following criteria:
• Location and extent (e.g., disuse osteoporosis, transitory osteoporosis, complex regional pain syndrome [CRPSI).
• Age at initial onset (e.g., idiopathic juvenile osteoporosis, postmenopausal osteoporosis, senile osteoporosis).
• Bone turnover rate (high and very high turnover, low turnover).
• Severity of the osteoporosis (normal, osteopenia, preclinical osteoporosis, and clinically manifest osteoporosis; severity Grades 0-3 according to Minne).
• Bone histology.
• Etiology.
372
An etiological classification based on more practical features:
• Primary osteoporosis: This includes postmenopausal and senile osteoporosis as well as primary osteoporosis of the male. It is the most common form and has many causes and risk factors, although some single pathogenetic factors are known. Although it involves the entire skeleton, it primarily affects the spine and proximal extremities.
• Secondary osteoporosis: This is considerably less common (about 5% of cases), but more often leads to osteoporotic fractures. It may be related to an underlying condition or medication (e.g., glucocorticoids) or may be of a genetic origin (e.g., Turner's syndrome, osteogenesis imperfecta). Typical disorders with an increased risk of osteoporosis include hypogonadism, hyperparathyroidism Cushing's disease, hyperthyroidism, chronic malabsorption syndrome, chronic inflammatory diseases, malignancies (especially multiple myeloma), and storage diseases.
> Clinical presentation. Osteoporosis is a silent condition, with few exceptions. Only after the development of macrofractures, either spontaneously or after minor injury, does the disease become apparent. Typical osteoporotic fra involve a vertebral body, the proximal femur, distal radius proximal humerus, and sacrum. Vertebral and hip fractures, in particular, result in increased mortality of those, typically older, patients who are affected since they have an additive effect with preexisting comorbidities. Osteoporotic vertebral fractures may also cause considerable back pain that is resistant to therapy. Referred pain can occur in a pseudoradicular distribution, but neurologic deficits are not part of the typical clinical course.
Clinical screening using bone density testing to identify individuals at risk for osteoporosis are becoming increasingly important given the typical asymptomatic course of the disease. Risk factors include hereditary predisposition, steroid therapy, nutritional calcium and/or vitamin D deficiency,
More
Less
Translation education
Other - J.W.Goethe Uni, Frankfurt
Experience
Years of experience: 35. Registered at ProZ.com: Nov 2007. Became a member: Sep 2025.
Retired Consultant General Surgeon with over 35 years of hands-on clinical experience and more than 25 years of professional translation experience from German into English. I trained and qualified in Germany and completed most of my surgical career in the UK, specialising in hand surgery.
I translate complex medical and pharmaceutical content for professional and regulatory audiences, combining deep subject-matter expertise with clear, idiomatic English. My work includes medical textbooks for Thieme Verlag, regular contributions to Deutsches Ärzteblatt, clinical trial documentation, regulatory and marketing authorisation materials, surgical publications, and peer-reviewed research articles.
I offer accurate, consistent, and terminology-driven translations tailored to the expectations of English-speaking clinicians, regulators, and researchers, with strict attention to quality assurance and client style guides.
This user has earned KudoZ points by helping other translators with PRO-level terms. Click point total(s) to see term translations provided.
Keywords: German to English medical translation, German to English medical translator, medical doctor and medical translator, Consultant General Surgeon, specialised in orthopaedics, plastic surgery, general medicine, internal medicine, cardiology, pharmaceutical. See more.German to English medical translation, German to English medical translator, medical doctor and medical translator, Consultant General Surgeon, specialised in orthopaedics, plastic surgery, general medicine, internal medicine, cardiology, pharmaceutical, translate medical reports, healthcare translation services, medical documents, surgical texts, academic articles, continuing education (CME) materials, terminology consistency using CAT tools and translation memory. Native English speaker, deep understanding of German medical terminology and clinical practice, medical doctor.. See less.
Member since Sep '25
Portfolio 